IPL Sublamination in Chicken Retinal Spheroids Is Initiated via Müller Cells and Cholinergic Differentiation, and Is Disrupted by NMDA Signaling | Zendy

Gesine Bachmann | Zendy; Florian Frohns | Zendy; Gopenath Thangaraj | Zendy; Andreas R. Bausch | Zendy; Paul G. Layer | Zendy

Open Access

IPL Sublamination in Chicken Retinal Spheroids Is Initiated via Müller Cells and Cholinergic Differentiation, and Is Disrupted by NMDA Signaling

Author(s) -

Gesine Bachmann,

Florian Frohns,

Gopenath Thangaraj,

Andreas R. Bausch,

Paul G. Layer

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24952

Subject(s) - inner plexiform layer , calretinin , choline acetyltransferase , microbiology and biotechnology , cholinergic , retina , glutamate receptor , biology , retinal , chemistry , neuroscience , receptor , immunology , biochemistry , immunohistochemistry

Reaggregates from E6 embryonic chicken retina exhibit areas corresponding to an inner plexiform layer (IPL), which presents an ideal in vitro model to test conditions and constraints of cholinergic and glutamatergic network formation, providing a basis for retinal tissue engineering. Here, we show that ipl formation is regulated by cholinergic starburst amacrine cells (SACs), a glial scaffold and by L-glutamate.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research