Open AccessMulti-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients
Author(s) -
Wojtek Drabarek,
Serdar Yavuzyiğitoğlu,
Askar Obulkasim,
Job van Riet,
Kyra N. Smit,
Natasha M. van Poppelen,
Jolanda Vaarwater,
Tom Brands,
Bert Eussen,
Robert M. Verdijk,
Nicole Naus,
Hanneke W. Mensink,
Dion Paridaens,
Eric Boersma,
Harmen J.G. van de Werken,
Emine Kılıç,
Annelies de Klein
Publication year - 2019
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.18-24818
Subject(s) - proportional hazards model , bap1 , hazard ratio , interquartile range , oncology , melanoma , snp , medicine , copy number variation , single nucleotide polymorphism , biology , genetics , cancer research , confidence interval , gene , genotype , genome
Uveal melanoma (UM) is characterized by multiple chromosomal rearrangements and recurrent mutated genes. The aim of this study was to investigate if copy number variations (CNV) alone and in combination with other genetic and clinico-histopathological variables can be used to stratify for disease-free survival (DFS) in enucleated patients with UM.