Surgical Removal of Internal Limiting Membrane and Layering of AAV Vector on the Retina Under Air Enhances Gene Transfection in a Nonhuman Primate | Zendy

Kelvin Yi Chong Teo | Zendy; Shu Yen Lee | Zendy; Veluchamy A. Barathi | Zendy; Sai Bo Bo Tun | Zendy; Licia Tan | Zendy; Ian J. Constable | Zendy

Open Access

Surgical Removal of Internal Limiting Membrane and Layering of AAV Vector on the Retina Under Air Enhances Gene Transfection in a Nonhuman Primate

Author(s) -

Kelvin Yi Chong Teo,

Shu Yen Lee,

Veluchamy A. Barathi,

Sai Bo Bo Tun,

Licia Tan,

Ian J. Constable

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24333

Subject(s) - transfection , green fluorescent protein , inner limiting membrane , colocalization , vitrectomy , ganglion cell layer , pars plana , ophthalmology , microbiology and biotechnology , retina , chemistry , biology , pathology , retinal , medicine , cell culture , visual acuity , gene , biochemistry , genetics , neuroscience

To determine if the surgical removal of the internal limiting membrane (ILM) in nonhuman primates (NHPs) will result in safe and effective transfection of adeno-associated viral (AAV2) vectors using green fluorescent protein (GFP) as a reporter.

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