3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis | Zendy

Charandeep Singh | Zendy; Amit Sharma | Zendy; George Hoppe | Zendy; Weilin Song | Zendy; Youstina Bolok | Zendy; Jonathan E. Sears | Zendy

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3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis

Author(s) -

Charandeep Singh,

Amit Sharma,

George Hoppe,

Weilin Song,

Youstina Bolok,

Jonathan E. Sears

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24120

Subject(s) - hypoxia (environmental) , microbiology and biotechnology , chemistry , hypoxia inducible factors , biology , oxygen , biochemistry , organic chemistry , gene

Transcriptional analysis of retina protected by hypoxia-inducible factor (HIF) stabilization demonstrates an increase in genes associated with aerobic glycolysis. We hypothesized that since protection is associated with a change in metabolism, oxygen-induced metabolites might transduce oxygen toxicity. We used global metabolic profiling to identify retinal metabolites increased in hyperoxia compared to normoxia.

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