Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells | Zendy

Laura Wernecke | Zendy; Susanne Keckeis | Zendy; Nadine Reichhart | Zendy; Olaf Strauß | Zendy; Daniel J. Salchow | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

Author(s) -

Laura Wernecke,

Susanne Keckeis,

Nadine Reichhart,

Olaf Strauß,

Daniel J. Salchow

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-23789

Subject(s) - transdifferentiation , mesenchymal stem cell , lens (geology) , microbiology and biotechnology , biology , stem cell , paleontology

Posterior capsule opacification (PCO) is a complication after cataract surgery, particularly in children. Epithelial-mesenchymal transition (EMT) of lens epithelial cells, mediated by transforming growth factor beta (TGFβ), contributes to PCO. However, its pathogenesis in children is poorly understood. We correlated cell growth in culture with patient characteristics, studied gene expression of pediatric lens epithelial cells (pLEC), and examined the effects of TGFβ-2 on these cells in vitro.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research