Open AccessSIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14
Author(s) -
Yong Lin,
Li Li,
Junjie Liu,
Xiaoting Zhao,
Juxiu Ye,
Peter S. Reinach,
Jia Qu,
Dongsheng Yan
Publication year - 2018
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.17-23558
Subject(s) - downregulation and upregulation , matrigel , angiogenesis , retinal , vascular endothelial growth factor , biology , microbiology and biotechnology , endothelial stem cell , vascular endothelial growth factor a , chemistry , cancer research , biochemistry , in vitro , gene , vegf receptors
Silent information regulator protein 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that is abundantly expressed in vascular endothelial cells (VECs), and it has an essential role in angiogenesis. However, its contribution to retinal vascular development remains unclear. Here we characterize its involvement in regulating this process under both physiological and pathologic conditions.