Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland | Zendy

Luis Fernando Nominato | Zendy; Ana Carolina Dias | Zendy; Lara Cristina Dias | Zendy; Marina Zílio Fantucci | Zendy; Lilian Eslaine Costa Mendes da Silva | Zendy; Adriana de Andrade Batista Murashima | Zendy; Eduardo Melani Rocha | Zendy

Open Access

Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland

Author(s) -

Luis Fernando Nominato,

Ana Carolina Dias,

Lara Cristina Dias,

Marina Zílio Fantucci,

Lilian Eslaine Costa Mendes da Silva,

Adriana de Andrade Batista Murashima,

Eduardo Melani Rocha

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22322

Subject(s) - lacrimal gland , corneal neovascularization , cornea , vascular endothelial growth factor , trigeminal ganglion , immunohistochemistry , medicine , microbiology and biotechnology , endocrinology , neovascularization , biology , pathology , ophthalmology , angiogenesis , vegf receptors , sensory system , neuroscience

The aims of this study were (1) to determine the efficacy of adenovirus vector serotype 5 (Ad) encoding human soluble VEGF receptor 1 (s-VEGFR1) gene transfer to the lacrimal gland (LG); (2) to investigate whether expression of s-VEGFR1 prevents corneal neovascularization (CNV) induced by alkali burns; and (3) to evaluate the safety of the procedure.

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