Open AccessElevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma
Author(s) -
Zhichao Yan,
Huanquan Liao,
Hongrui Chen,
Shuifeng Deng,
Yu Jia,
Caibin Deng,
Jintian Lin,
Junbo Ge,
Yehong Zhuo
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.17-22312
Subject(s) - lateral geniculate nucleus , senile plaques , glaucoma , neuroscience , neuropathology , retina , tauopathy , pathology , geniculate , biology , alzheimer's disease , chemistry , medicine , nucleus , neurodegeneration , disease
Recent evidence has suggested a potential association between Alzheimer's disease (AD) and glaucoma and found significant deposition of amyloid-β (Aβ) and Tau protein in the retinas of glaucoma patients. However, no coherent finding has emerged regarding the AD-like changes in the central visual system (CVS). Studies confirming the presence of Aβ and Tau neuropathology are warranted to identify the underlying mechanism that contributes to the visual impairment observed in glaucoma.