Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography | Zendy

Jens Horstmann | Zendy; Hinnerk SchulzHildebrandt | Zendy; Felix Bock | Zendy; Sebastian Siebelmann | Zendy; Eva Lankenau | Zendy; Gereon Hüttmann | Zendy; Philipp Steven | Zendy; Claus Cursiefen | Zendy

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Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography

Author(s) -

Jens Horstmann,

Hinnerk SchulzHildebrandt,

Felix Bock,

Sebastian Siebelmann,

Eva Lankenau,

Gereon Hüttmann,

Philipp Steven,

Claus Cursiefen

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22286

Subject(s) - lymphatic system , optical coherence tomography , lymphatic vessel , lumen (anatomy) , corneal neovascularization , lymphangiogenesis , cd31 , neovascularization , cornea , pathology , medicine , stain , anatomy , ophthalmology , immunohistochemistry , biomedical engineering , angiogenesis , staining , surgery , cancer , metastasis

Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT).

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