Tissue Transglutaminase Elevates Intraocular Pressure in Mice | Zendy

Urmimala Raychaudhuri | Zendy; J. Cameron Millar | Zendy; Abbot F. Clark | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Tissue Transglutaminase Elevates Intraocular Pressure in Mice

Author(s) -

Urmimala Raychaudhuri,

J. Cameron Millar,

Abbot F. Clark

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22236

Subject(s) - intraocular pressure , immunocytochemistry , trabecular meshwork , aqueous humor , tissue transglutaminase , microbiology and biotechnology , chemistry , extracellular , ophthalmology , multiplicity of infection , andrology , biology , endocrinology , medicine , in vitro , enzyme , biochemistry

Tissue transglutaminase (TGM2) is elevated in glaucomatous trabecular meshwork (TM) tissues. We investigated whether increased expression of TGM2 increases extracellular matrix crosslinking in the TM, thereby increasing aqueous humor outflow resistance and elevating intraocular pressure (IOP) in mouse eyes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research