Benzo(e)pyrene Inhibits Endothelium-Dependent NO-Mediated Dilation of Retinal Arterioles via Superoxide Production and Endoplasmic Reticulum Stress | Zendy

Takayuki Kamiya | Zendy; Taiji Nagaoka | Zendy; Tsuneaki Omae | Zendy; Shinji Ono | Zendy; Shinichi Otani | Zendy; Akitoshi Yoshida | Zendy

Open Access

Benzo(e)pyrene Inhibits Endothelium-Dependent NO-Mediated Dilation of Retinal Arterioles via Superoxide Production and Endoplasmic Reticulum Stress

Author(s) -

Takayuki Kamiya,

Taiji Nagaoka,

Tsuneaki Omae,

Shinji Ono,

Shinichi Otani,

Akitoshi Yoshida

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21925

Subject(s) - apocynin , bradykinin , chemistry , superoxide , nadph oxidase , vasodilation , xanthine oxidase , pharmacology , sodium nitroprusside , xanthine oxidase inhibitor , nitric oxide , endocrinology , biochemistry , oxidative stress , biology , enzyme , receptor , organic chemistry

To investigate whether benzo(e)pyrene (B(e)P), a toxicant in cigarette smoke, affects the endothelium-dependent nitric oxide (NO)-induced vasodilation of the retinal arterioles, and whether oxidative stress, distinct protein kinase signaling pathways, and endoplasmic reticulum (ER) stress are associated with the B(e)P-induced effect on the retinal arterioles.

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