Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration | Zendy

Riccardo Natoli | Zendy; Nilisha Fernando | Zendy; Haihan Jiao | Zendy; Tanja Racic | Zendy; Michele C. Madigan | Zendy; Nigel L. Barnett | Zendy; Joshua A. ChuTan | Zendy; Krisztina Valter | Zendy; Jan Provis | Zendy; Matt Rutar | Zendy

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Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration

Author(s) -

Riccardo Natoli,

Nilisha Fernando,

Haihan Jiao,

Tanja Racic,

Michele C. Madigan,

Nigel L. Barnett,

Joshua A. ChuTan,

Krisztina Valter,

Jan Provis,

Matt Rutar

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21672

Subject(s) - macular degeneration , microglia , retina , retinal , complement system , retinal degeneration , lesion , biology , alternative complement pathway , pathology , factor h , microbiology and biotechnology , immunology , medicine , neuroscience , inflammation , immune system , ophthalmology , biochemistry

Complement system dysregulation is strongly linked to the progression of age-related macular degeneration (AMD). Deposition of complement including C3 within the lesions in atrophic AMD is thought to contribute to lesion growth, although the contribution of local cellular sources remains unclear. We investigated the role of retinal microglia and macrophages in complement activation within atrophic lesions, in AMD and in models of focal retinal degeneration.

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