TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus | Zendy

Muneeza Arbab | Zendy; Saira Tahir | Zendy; Muhammad Khizar Niazi | Zendy; Mazhar Ishaq | Zendy; Alamdar Hussain | Zendy; Pir Muhammad Siddique | Zendy; Sadia Saeed | Zendy; Wajid Ali Khan | Zendy; Raheel Qamar | Zendy; Azeem Mehmood Butt | Zendy; Maleeha Azam | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus

Author(s) -

Muneeza Arbab,

Saira Tahir,

Muhammad Khizar Niazi,

Mazhar Ishaq,

Alamdar Hussain,

Pir Muhammad Siddique,

Sadia Saeed,

Wajid Ali Khan,

Raheel Qamar,

Azeem Mehmood Butt,

Maleeha Azam

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21400

Subject(s) - genotype , pathogenesis , tumor necrosis factor alpha , microbiology and biotechnology , allele , odds ratio , promoter , interleukin 6 , tumor necrosis factor receptor 1 , biology , immunology , medicine , gene , cytokine , gene expression , genetics , tumor necrosis factor receptor

To date keratoconus (KC) pathogenesis is undefined; however, the involvement of inflammatory pathways in disease development is becoming apparent. In the present study, we investigated the role of a promoter region polymorphism rs1800629 (-308G>A) in the inflammatory pathway component TNF-α and its effects on the expression of TNF-α and downstream molecules tumor necrosis factor receptor 1 and 2 (TNFR1 and TNFR2), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and interleukin 6 (IL-6) in KC development.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research