Intraocular Delivery of miR-146 Inhibits Diabetes-Induced Retinal Functional Defects in Diabetic Rat Model | Zendy

Pei Zhuang | Zendy; Chithra Muraleedharan | Zendy; Shunbin Xu | Zendy

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Intraocular Delivery of miR-146 Inhibits Diabetes-Induced Retinal Functional Defects in Diabetic Rat Model

Author(s) -

Pei Zhuang,

Chithra Muraleedharan,

Shunbin Xu

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21223

Subject(s) - retinal , diabetic retinopathy , retina , intravitreal administration , downregulation and upregulation , diabetes mellitus , in vivo , streptozotocin , biology , medicine , microbiology and biotechnology , endocrinology , ophthalmology , biochemistry , neuroscience , gene

Previously, we showed that microRNA-146 (miR-146) is a pivotal negative feedback regulator of multiple nuclear factor kappa-B (NF-κB) activation pathways in retinal endothelial cells (RECs). We hypothesized that miR-146 plays an important role in diabetic retinopathy (DR) by inhibiting diabetes-induced inflammatory response in the retina. The purpose of the current study is to test this hypothesis in vivo.

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