Loss of Tryptophan Fluorescence Correlates With Mechanical Stiffness Following Photo-Crosslinking Treatment of Rabbit Cornea | Zendy

Maura Williams | Zendy; W. David Lewis | Zendy; Walfre Franco | Zendy

Open Access

Loss of Tryptophan Fluorescence Correlates With Mechanical Stiffness Following Photo-Crosslinking Treatment of Rabbit Cornea

Author(s) -

Maura Williams,

W. David Lewis,

Walfre Franco

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20750

Subject(s) - keratoconus , cornea , riboflavin , fluorescence , chemistry , dextran , biophysics , materials science , ophthalmology , optics , chromatography , medicine , biochemistry , biology , physics

A clinical treatment option for keratoconus involves the use of UV-initiated photo-crosslinking with riboflavin to increase corneal stiffness. Our study investigates whether endogenous fluorescence changes following treatment for keratoconus can be correlated to alterations in the stiffness of the cornea, thereby guiding treatment of keratoconus.

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