Ocular Delivery of PACAP1-27 Protects the Retina From Ischemic Damage in Rodents | Zendy

Dóra Werling | Zendy; Dóra Reglődi | Zendy; William A. Banks | Zendy; Therese S. Salameh | Zendy; Krisztina Kovács | Zendy; Tímea Kvárik | Zendy; Alexandra Váczy | Zendy; László Kovács | Zendy; F. Mayer | Zendy; Bese Dányádi | Zendy; Emese Lokos | Zendy; Andrea Tamás | Zendy; Gábor K. Tóth | Zendy; Zsolt Bíró | Zendy; Tamás Atlasz | Zendy

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Ocular Delivery of PACAP1-27 Protects the Retina From Ischemic Damage in Rodents

Author(s) -

Dóra Werling,

Dóra Reglődi,

William A. Banks,

Therese S. Salameh,

Krisztina Kovács,

Tímea Kvárik,

Alexandra Váczy,

László Kovács,

F. Mayer,

Bese Dányádi,

Emese Lokos,

Andrea Tamás,

Gábor K. Tóth,

Zsolt Bíró,

Tamás Atlasz

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20630

Subject(s) - medicine , retina , ophthalmology , neuroprotection , ophthalmic artery , common carotid artery , downregulation and upregulation , retinal , ischemia , anesthesia , pharmacology , carotid arteries , chemistry , neuroscience , biology , blood flow , biochemistry , gene

Pituitary adenylate cyclase activating polypeptide (PACAP) is neuroprotective in neuronal injuries. Bilateral common carotid artery occlusion (BCCAO) causes chronic hypoperfusion-induced degeneration in the rat retina, where we proved the retinoprotective effect of intravitreal PACAP. Although this route of administration is a common clinical practice in several diseases, easier routes are clinically important. Our aim was to investigate the potential retinoprotective effects of PACAP eye drops in BCCAO-induced ischemic retinopathy.

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