Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells | Zendy

Sébastien P. Gendron | Zendy; Mathieu Thériault | Zendy; Stéphanie Proulx | Zendy; Isabelle Brunette | Zendy; Patrick J. Rochette | Zendy

Open Access

Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells

Author(s) -

Sébastien P. Gendron,

Mathieu Thériault,

Stéphanie Proulx,

Isabelle Brunette,

Patrick J. Rochette

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20551

Subject(s) - corneal endothelium , oxidative stress , telomere , biology , programmed cell death , microbiology and biotechnology , mitochondrion , mitochondrial dna , oxidative phosphorylation , reactive oxygen species , telomerase , endothelium , apoptosis , genetics , gene , biochemistry

Fuchs' endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium that leads to vision loss, is a leading cause of corneal transplantation. The cause of this disease is still unknown, but the implication of oxidative stress is strongly suggested. In this study, we analyzed the impact of FECD on mitochondrial DNA (mtDNA) integrity and telomere length, both of which are affected by the oxidative status of the cell.

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