High Mitochondrial DNA Copy Number Is a Protective Factor From Vision Loss in Heteroplasmic Leber's Hereditary Optic Neuropathy (LHON) | Zendy

Angelica Bianco | Zendy; Luigi Bisceglia | Zendy; Luciana Russo | Zendy; Luigi Leonardo Palese | Zendy; Leonardo D’Agruma | Zendy; Sonia Emperador | Zendy; Julio Montoya | Zendy; Silvana Guerriero | Zendy; Vittoria Petruzzella | Zendy

Open Access

High Mitochondrial DNA Copy Number Is a Protective Factor From Vision Loss in Heteroplasmic Leber's Hereditary Optic Neuropathy (LHON)

Author(s) -

Angelica Bianco,

Luigi Bisceglia,

Luciana Russo,

Luigi Leonardo Palese,

Leonardo D’Agruma,

Sonia Emperador,

Julio Montoya,

Silvana Guerriero,

Vittoria Petruzzella

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20389

Subject(s) - heteroplasmy , leber's hereditary optic neuropathy , mitochondrial dna , optic neuropathy , genetics , medicine , ophthalmology , biology , gene , optic nerve

Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease that typically causes bilateral blindness in young men. It is characterized by as yet undisclosed genetic and environmental factors affecting the incomplete penetrance.

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