Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid–Independent Pathway | Zendy

Antionette L. Williams | Zendy; Jessica Eason | Zendy; Bahaar Chawla | Zendy; Brenda L. Bohnsack | Zendy

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Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid–Independent Pathway

Author(s) -

Antionette L. Williams,

Jessica Eason,

Bahaar Chawla,

Brenda L. Bohnsack

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20235

Subject(s) - cyp1b1 , closure (psychology) , retinoic acid , chemistry , ophthalmology , medicine , biochemistry , gene , economics , cytochrome p450 , metabolism , market economy

Mutations in the CYP1B1 gene are the most commonly identified genetic causes of primary infantile-onset glaucoma. Despite this disease association, the role of CYP1B1 in eye development and its in vivo substrate remain unknown. In the present study, we used zebrafish to elucidate the mechanism by which cyp1b1 regulates eye development.

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