Activation of the Rho/Rho Kinase Signaling Pathway Is Involved in Cell Death of Corneal Endothelium | Zendy

Naoki Okumura | Zendy; Keita Fujii | Zendy; Takato Kagami | Zendy; Nakahara Makiko | Zendy; Miu Kitahara | Zendy; Shigeru Kinoshita | Zendy; Noriko Koizumi | Zendy

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Activation of the Rho/Rho Kinase Signaling Pathway Is Involved in Cell Death of Corneal Endothelium

Author(s) -

Naoki Okumura,

Keita Fujii,

Takato Kagami,

Nakahara Makiko,

Miu Kitahara,

Shigeru Kinoshita,

Noriko Koizumi

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20123

Subject(s) - focal adhesion , rhoa , microbiology and biotechnology , annexin , apoptosis , rho associated protein kinase , chemistry , phosphorylation , tunel assay , programmed cell death , signal transduction , biology , biochemistry

Rho kinase (ROCK) pathways control fundamental cell functions, making ROCK an important therapeutic target in several pathophysiologic conditions. The purpose of this study was to investigate whether inhibition of ROCK can suppress apoptosis of the corneal endothelium and to determine the role of ROCK signaling in regulating apoptosis.

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