Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming | Zendy

Ying-Hsuan Shih | Zendy; Monte J. Radeke | Zendy; Carolyn M. Radeke | Zendy; Peter Coffey | Zendy

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Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming

Author(s) -

Ying-Hsuan Shih,

Monte J. Radeke,

Carolyn M. Radeke,

Peter Coffey

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20018

Subject(s) - reprogramming , transcription factor , mesenchymal stem cell , microbiology and biotechnology , biology , genetics , gene

Transforming growth factor β-mediated epithelial-to-mesenchymal transition (EMT) is a major component of the wound healing response and a negative determinant of retinal pigment epithelium (RPE) differentiation. We have shown previously that inhibition of TGFβ signaling restored the capacity of mesenchymal RPE to differentiate; however, the potential lessens with extensive passaging. We investigated TGFβ-independent mechanisms that regulate RPE differentiation following repetitive passaging.

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