Open AccessGalectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis
Author(s) -
WeiSheng Chen,
Zhiyi Cao,
Hakon Leffler,
Ulf J. Nilsson,
Noorjahan Panjwani
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-20009
Subject(s) - corneal neovascularization , angiogenesis , neovascularization , fibrosis , cornea , pathology , galectin 3 , cancer research , medicine , ophthalmology
Corneal neovascularization and scarring commonly lead to significant vision loss. This study was designed to determine whether a small-molecule inhibitor of galectin-3 can inhibit both corneal angiogenesis and fibrosis in experimental mouse models.
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