Modeling the Chronic Loss of Optic Nerve Axons and the Effects on the Retinal Nerve Fiber Layer Structure in Primary Disorder of Myelin | Zendy

Leandro B. C. Teixeira | Zendy; James N. Ver Hoeve | Zendy; Joshua A. Mayer | Zendy; Richard R. Dubielzig | Zendy; Chelsey M. Smith | Zendy; Abigail B. Radcliff | Zendy; Ian D. Duncan | Zendy

Open Access

Modeling the Chronic Loss of Optic Nerve Axons and the Effects on the Retinal Nerve Fiber Layer Structure in Primary Disorder of Myelin

Author(s) -

Leandro B. C. Teixeira,

James N. Ver Hoeve,

Joshua A. Mayer,

Richard R. Dubielzig,

Chelsey M. Smith,

Abigail B. Radcliff,

Ian D. Duncan

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19871

Subject(s) - retinal , optic nerve , nerve fiber layer , axon , retina , retinal ganglion cell , ophthalmology , optical coherence tomography , medicine , myelin , nerve fiber , electroretinography , anatomy , biology , neuroscience , central nervous system

We determined whether the chronic lack of optic nerve myelination and subsequent axon loss is associated with optical coherence tomography (OCT) changes in the retinal nerve fiber layer (RNFL), and whether this models what occurs in multiple sclerosis (MS) and confers its use as a surrogate marker for axon degeneration.

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