Integrin α5β1 Inhibition by CLT-28643 Reduces Postoperative Wound Healing in a Mouse Model of Glaucoma Filtration Surgery | Zendy

Tine Van Bergen | Zendy; Grit Zahn | Zendy; Patrizia Caldirola | Zendy; Mario G. Fsadni | Zendy; Ninus CaramLelham | Zendy; Evelien Vandewalle | Zendy; Lieve Moons | Zendy; Ingeborg Stalmans | Zendy

Open Access

Integrin α5β1 Inhibition by CLT-28643 Reduces Postoperative Wound Healing in a Mouse Model of Glaucoma Filtration Surgery

Author(s) -

Tine Van Bergen,

Grit Zahn,

Patrizia Caldirola,

Mario G. Fsadni,

Ninus CaramLelham,

Evelien Vandewalle,

Lieve Moons,

Ingeborg Stalmans

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19751

Subject(s) - medicine , bleb (medicine) , immunostaining , integrin , wound healing , glaucoma surgery , surgery , angiogenesis , mitomycin c , toxicity , glaucoma , trabeculectomy , pharmacology , pathology , ophthalmology , immunohistochemistry , receptor

To evaluate the therapeutic potential of the small molecule integrin α5β1 inhibitor, CLT-28643, to improve the filtering surgery outcome in a mouse model. Different dose regimens and administration routes of the inhibitor were compared with mitomycin C (MMC), the gold standard in clin ical practice.

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