The Eye as a Window to the Brain: Neuroretinal Thickness Is Associated With Microstructural White Matter Injury in HIV-Infected Children | Zendy

Charlotte Blokhuis | Zendy; Nazli Demirkaya | Zendy; Sophie Cohen | Zendy; Ferdinand W.N.M. Wit | Zendy; Henriëtte J. Scherpbier | Zendy; Peter Reiss | Zendy; Michael D. Abràmoff | Zendy; Matthan W.A. Caan | Zendy; Charles B.L.M. Majoie | Zendy; Frank D. Verbraak | Zendy; Dasja Pajkrt | Zendy

Open Access

The Eye as a Window to the Brain: Neuroretinal Thickness Is Associated With Microstructural White Matter Injury in HIV-Infected Children

Author(s) -

Charlotte Blokhuis,

Nazli Demirkaya,

Sophie Cohen,

Ferdinand W.N.M. Wit,

Henriëtte J. Scherpbier,

Peter Reiss,

Michael D. Abràmoff,

Matthan W.A. Caan,

Charles B.L.M. Majoie,

Frank D. Verbraak,

Dasja Pajkrt

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19716

Subject(s) - white matter , window (computing) , ophthalmology , medicine , human immunodeficiency virus (hiv) , optometry , virology , magnetic resonance imaging , computer science , radiology , operating system

Despite combination antiretroviral therapy (cART), perinatal HIV-infection can cause decreased gray and white matter volume, microstructural white matter injury, and retinal structural abnormalities. As neuroretinal tissue is directly connected to the brain, these deficits may have a shared pathogenesis. We aimed to assess associations between neuroretinal thickness and cerebral injury in cART-treated perinatally HIV-infected children and healthy controls.

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