Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus | Zendy

Natasha Pahuja | Zendy; N. Rajiv Kumar | Zendy; Rushad Shroff | Zendy; Rohit Shetty | Zendy; Rudy M.M.A. Nuijts | Zendy; Anuprita Ghosh | Zendy; Abhijit Sinha Roy | Zendy; Shyam S. Chaurasia | Zendy; Rajiv R. Mohan | Zendy; Arkasubhra Ghosh | Zendy

Open Access

Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus

Author(s) -

Natasha Pahuja,

N. Rajiv Kumar,

Rushad Shroff,

Rohit Shetty,

Rudy M.M.A. Nuijts,

Anuprita Ghosh,

Abhijit Sinha Roy,

Shyam S. Chaurasia,

Rajiv R. Mohan,

Arkasubhra Ghosh

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19677

Subject(s) - keratoconus , apex (geometry) , cornea , matrix metalloproteinase , ophthalmology , pathology , stromal cell , extracellular matrix , medicine , gene expression , anatomy , biology , chemistry , microbiology and biotechnology , gene , biochemistry

In this study, we elucidated the differential expression of a set of local molecular factors in ectatic cone area of the cornea to uncover a functional cause for focal corneal weakening characteristic of the keratoconus (KC) disease.

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