Lentiviral Delivery of Small Hairpin RNA Targeting Connective Tissue Growth Factor Blocks Profibrotic Signaling in Tenon's Capsule Fibroblasts | Zendy

Dawei Lei | Zendy; Changgui Dong | Zendy; William Ka Kei Wu | Zendy; Aimeng Dong | Zendy; Tingting Li | Zendy; Matthew T.V. Chan | Zendy; Xinrong Zhou | Zendy; Huiping Yuan | Zendy

Open Access

Lentiviral Delivery of Small Hairpin RNA Targeting Connective Tissue Growth Factor Blocks Profibrotic Signaling in Tenon's Capsule Fibroblasts

Author(s) -

Dawei Lei,

Changgui Dong,

William Ka Kei Wu,

Aimeng Dong,

Tingting Li,

Matthew T.V. Chan,

Xinrong Zhou,

Huiping Yuan

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19480

Subject(s) - ctgf , growth factor , small hairpin rna , microbiology and biotechnology , gene knockdown , fibrosis , cancer research , chemistry , biology , medicine , pathology , apoptosis , biochemistry , receptor

Trabeculectomy is a surgical procedure for lowering intraocular pressure in glaucoma patients, in which excessive scarring leading to failure of the filtering bleb adversely affects the surgical outcome. Heightened Tenon's capsule fibroblast (TCF) proliferation and extracellular matrix (ECM) deposition are implicated in this process but endogenous factors that regulate TCF functions remain largely elusive. This study sought to elucidate the role of connective tissue growth factor (CTGF) in the regulation of TCF phenotypes and signaling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research