Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx3Cv Mouse Model of Duchenne Muscular Dystrophy | Zendy

Tina I. Tsai | Zendy; Mirella Telles Salgueiro Barboni | Zendy; Balázs Vince Nagy | Zendy; Michel Roux | Zendy; Álvaro Rendón | Zendy; Dora Fix Ventura | Zendy; Jan Kremers | Zendy

Open Access

Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx^3Cv Mouse Model of Duchenne Muscular Dystrophy

Author(s) -

Tina I. Tsai,

Mirella Telles Salgueiro Barboni,

Balázs Vince Nagy,

Michel Roux,

Álvaro Rendón,

Dora Fix Ventura,

Jan Kremers

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19432

Subject(s) - photopic vision , scotopic vision , mesopic vision , electroretinography , retinal , erg , biology , ophthalmology , medicine

The dystrophin mouse mutant mdx3Cv exhibits scotopic electroretinograpic (ERG) abnormalities, which resemble clinical changes observed in Duchenne muscular dystrophy (DMD) patients. In the present study, ERGs obtained from mdx3Cv and their wild-type littermates under scotopic, mesopic, and photopic conditions were analyzed to provide further insight on the affected retinal pathways, and to compare them with human data.

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