Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model | Zendy

Sally Miller | Zendy; Emma Leishman | Zendy; Sherry ShuJung Hu | Zendy; Alhasan N. Elghouche | Zendy; Laura Daily | Zendy; Natalia Murataeva | Zendy; Heather B. Bradshaw | Zendy; Alex Straiker | Zendy

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Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model

Author(s) -

Sally Miller,

Emma Leishman,

Sherry ShuJung Hu,

Alhasan N. Elghouche,

Laura Daily,

Natalia Murataeva,

Heather B. Bradshaw,

Alex Straiker

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19356

Subject(s) - monoacylglycerol lipase , endocannabinoid system , cannabinoid receptor , 2 arachidonoylglycerol , pharmacology , cannabinoid , diacylglycerol lipase , anandamide , chemistry , endogeny , medicine , receptor , agonist , biochemistry

Cannabinoids, such as Δ9-THC, act through an endogenous signaling system in the vertebrate eye that reduces IOP via CB1 receptors. Endogenous cannabinoid (eCB) ligand, 2-arachidonoyl glycerol (2-AG), likewise activates CB1 and is metabolized by monoacylglycerol lipase (MAGL). We investigated ocular 2-AG and its regulation by MAGL and the therapeutic potential of harnessing eCBs to lower IOP.

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