The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions | Zendy

H. Jacey | Zendy; Joshua J. Wang | Zendy; Junhua Li | Zendy; Bruce A. Pfeffer | Zendy; Yiming Zhong | Zendy; Sarah X. Zhang | Zendy

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The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions

Author(s) -

H. Jacey,

Joshua J. Wang,

Junhua Li,

Bruce A. Pfeffer,

Yiming Zhong,

Sarah X. Zhang

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19232

Subject(s) - tight junction , rhoa , microbiology and biotechnology , unfolded protein response , xbp1 , endoplasmic reticulum , thapsigargin , occludin , rho associated protein kinase , downregulation and upregulation , chemistry , tunicamycin , biology , kinase , signal transduction , biochemistry , rna splicing , rna , gene

The retinal pigment epithelium (RPE) tight junctions play a pivotal role in maintaining the homeostatic environment of the neural retina. Herein, we investigated the role of X-box binding protein 1 (XBP1), an endoplasmic reticulum (ER) stress-responsive transcription factor, in regulation of RPE tight junctions.

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