Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells | Zendy

Dorette Z. Ellis | Zendy; Linya Li | Zendy; Yong H. Park | Zendy; Shaoqing He | Zendy; Brett Mueller | Zendy; Thomas Yorio | Zendy

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Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells

Author(s) -

Dorette Z. Ellis,

Linya Li,

Yong H. Park,

Shaoqing He,

Brett Mueller,

Thomas Yorio

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19199

Subject(s) - mitochondrion , biology , mitochondrial apoptosis induced channel , cytochrome c , cytochrome c oxidase , inner mitochondrial membrane , microbiology and biotechnology , membrane potential , biochemistry

Understanding the role of mitochondria in retinal ganglion cells (RGCs) is relevant to human disease as studies have shown mitochondrial abnormalities in primary open-angle glaucoma patients. This study seeks to determine the effects of the sigma-1 receptor (σ-1r) and its agonists on mitochondrial function in oxygen- and glucose- deprived (OGD) purified neonatal RGCs.

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