Secretion Profile of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium During Wound Healing | Zendy

Whitney A. Greene | Zendy; Teresa A Burke | Zendy; Elaine D. Por | Zendy; Ramesh R. Kaini | Zendy; HeuyChing Wang | Zendy

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Secretion Profile of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium During Wound Healing

Author(s) -

Whitney A. Greene,

Teresa A Burke,

Elaine D. Por,

Ramesh R. Kaini,

HeuyChing Wang

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19192

Subject(s) - retinal pigment epithelium , wound healing , induced pluripotent stem cell , secretion , microbiology and biotechnology , retinal , stem cell , epithelium , ophthalmology , biology , medicine , pathology , immunology , embryonic stem cell , endocrinology , biochemistry , gene

The purpose of this study was to characterize the secretion profile of induced pluripotent stem cell-derived retinal pigment epithelium (iPS-RPE) during wound healing. iPS-RPE was used to develop an in vitro wound healing model. We hypothesized that iPS-RPE secretes cytokines and growth factors which act in an autocrine manner to promote migration and proliferation of cells during wound healing.

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