Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy | Zendy

Tiago SantosFerreira | Zendy; Manuela Völkner | Zendy; Oliver Borsch | Zendy; Jochen Haas | Zendy; Peter Cimalla | Zendy; Praveen Vasudevan | Zendy; Peter Carmeliet | Zendy; Denis Corbeil | Zendy; Stylianos Michalakis | Zendy; Edmund Koch | Zendy; Michael Karl | Zendy; Marius Ader | Zendy

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Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy

Author(s) -

Tiago SantosFerreira,

Manuela Völkner,

Oliver Borsch,

Jochen Haas,

Peter Cimalla,

Praveen Vasudevan,

Peter Carmeliet,

Denis Corbeil,

Stylianos Michalakis,

Edmund Koch,

Michael Karl,

Marius Ader

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19087

Subject(s) - retinitis pigmentosa , photoreceptor cell , retinal degeneration , biology , transplantation , microbiology and biotechnology , retina , rhodopsin , retinal regeneration , induced pluripotent stem cell , stem cell , retinal , ribbon synapse , regeneration (biology) , visual phototransduction , embryonic stem cell , pathology , neuroscience , medicine , genetics , biochemistry , vesicle , membrane , gene , synaptic vesicle

Preclinical studies on photoreceptor transplantation provided evidence for restoration of visual function with pluripotent stem cells considered as a potential source for sufficient amounts of donor material. Adequate preclinical models representing retinal disease conditions of potential future patients are needed for translation research. Here we compared transplant integration in mouse models with mild (prominin1-deficient; Prom1-/-) or severe (cone photoreceptor function loss 1/rhodopsin-deficient double-mutant; Cpfl1/Rho-/-) cone-rod degeneration.

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