Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy | Zendy

Jung Woo Byun | Zendy; Sena Hwang | Zendy; Chan Woo Kang | Zendy; Jin Hee Kim | Zendy; Min Kyung Chae | Zendy; Jin Sook Yoon | Zendy; Eun Jig Lee | Zendy

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Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy

Author(s) -

Jung Woo Byun,

Sena Hwang,

Chan Woo Kang,

Jin Hee Kim,

Min Kyung Chae,

Jin Sook Yoon,

Eun Jig Lee

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-19037

Subject(s) - western blot , adipogenesis , chemistry , in vitro , antioxidant , lipid peroxidation , peroxisome proliferator activated receptor , protocatechuic acid , heme oxygenase , biochemistry , pharmacology , heme , receptor , biology , enzyme , gene

Protocatechuic aldehyde (3,4-dihydroxybenzaldehyde; PCA) is extracted from Salvia miltiorrhiza, and has been reported to possess antiproliferative, antioxidant, and antiadipogenesis properties in various in vivo and in vitro experiments. This study aimed to outline the antioxidant and suppressive effects of PCA on adipogenesis and hyaluronan production in orbital fibroblasts to help with designing therapeutic approaches for Graves' orbitopathy (GO).

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