Open AccessHyperglycemia Enhances the Production of Amyloid β1–42 in the Lenses of Otsuka Long-Evans Tokushima Fatty Rats, a Model of Human Type 2 Diabetes
Author(s) -
Noriaki Nagai,
Yoshimasa Ito,
Hiroshi Sasaki
Publication year - 2016
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.15-19026
Subject(s) - endocrinology , medicine , lens (geology) , diabetes mellitus , amyloid (mycology) , type 2 diabetes , messenger rna , chemistry , biology , gene , biochemistry , inorganic chemistry , paleontology
It has been reported that the accumulation of amyloid β1-42 (Aβ1-42) in human lenses can cause some forms of lens opacification. However, the factors leading to changes in the accumulation of Aβ in the lens remain obscure. In this study, we investigate the effect of hyperglycemia on Aβ1-42 accumulation in lenses.