MRI Evidence of Cerebellar and Extraocular Muscle Atrophy Differently Contributing to Eye Movement Abnormalities in SCA2 and SCA28 Diseases | Zendy

Letterio S. Politi | Zendy; Stefania Bianchi Marzoli | Zendy; Claudia Godi | Zendy; Marta Panzeri | Zendy; Paola Ciasca | Zendy; Gianluca Brugnara | Zendy; Anna Castaldo | Zendy; Daniela Di Bella | Zendy; Franco Taroni | Zendy; Lorenzo Nanetti | Zendy; Caterina Mariotti | Zendy

Open Access

MRI Evidence of Cerebellar and Extraocular Muscle Atrophy Differently Contributing to Eye Movement Abnormalities in SCA2 and SCA28 Diseases

Author(s) -

Letterio S. Politi,

Stefania Bianchi Marzoli,

Claudia Godi,

Marta Panzeri,

Paola Ciasca,

Gianluca Brugnara,

Anna Castaldo,

Daniela Di Bella,

Franco Taroni,

Lorenzo Nanetti,

Caterina Mariotti

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18732

Subject(s) - extraocular muscles , pons , cerebellum , eye movement , saccadic masking , spinocerebellar ataxia , midbrain , anatomy , magnetic resonance imaging , medicine , brainstem , psychology , neuroscience , ataxia , ophthalmology , central nervous system , radiology

Spinocerebellar ataxias type 2 and 28 (SCA2, SCA28) are autosomal dominant disorders characterized by progressive cerebellar and oculomotor abnormalities. We aimed to investigate cerebellar, brainstem, and extraocular muscle involvement in the mitochondrial SCA28 disease compared with SCA2.

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