Neuropilin-1–Expressing Microglia Are Associated With Nascent Retinal Vasculature Yet Dispensable for Developmental Angiogenesis | Zendy

Agnieszka Dejda | Zendy; Gaëlle Mawambo | Zendy; JeanFrançois Daudelin | Zendy; Khalil Miloudi | Zendy; Naoufal Akla | Zendy; Chintan Patel | Zendy; Elisabeth M. M. A. Andriessen | Zendy; Nathalie Labrecque | Zendy; Florian Sennlaub | Zendy; Przemysław Sapieha | Zendy

Open Access

Neuropilin-1–Expressing Microglia Are Associated With Nascent Retinal Vasculature Yet Dispensable for Developmental Angiogenesis

Author(s) -

Agnieszka Dejda,

Gaëlle Mawambo,

JeanFrançois Daudelin,

Khalil Miloudi,

Naoufal Akla,

Chintan Patel,

Elisabeth M. M. A. Andriessen,

Nathalie Labrecque,

Florian Sennlaub,

Przemysław Sapieha

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18598

Subject(s) - microglia , retinal , angiogenesis , neuropilin 1 , biology , retina , microbiology and biotechnology , semaphorin , neuroscience , immunology , vascular endothelial growth factor , cancer research , inflammation , receptor , genetics , biochemistry , vegf receptors

Neuropilin-1 (NRP-1) is a transmembrane receptor that is critical for vascular development within the central nervous system (CNS). It binds and influences signaling of several key angiogenic factors, such as VEGF-165, semaphorin 3A, platelet derived growth factor, and more. Neuropilin-1 is expressed by neurons and endothelial cells as well as a subpopulation of proangiogenic macrophages/microglia that are thought to interact with endothelial tip cells to promote vascular anastomosis during brain vascularization. We previously demonstrated a significant role for NRP-1 in macrophage chemotaxis and showed that NRP-1-expressing microglia are major contributors to pathologic retinal angiogenesis. Given this influence on CNS angiogenesis, we now investigated the involvement of microglia-resident NRP-1 in developmental retinal vascularization.

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