Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation | Zendy

Yong H. Park | Zendy; Heather V. Broyles | Zendy; Shaoqing He | Zendy; Nolan R. McGrady | Zendy; Linya Li | Zendy; Thomas Yorio | Zendy

Open Access

Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation

Author(s) -

Yong H. Park,

Heather V. Broyles,

Shaoqing He,

Nolan R. McGrady,

Linya Li,

Thomas Yorio

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18481

Subject(s) - ampa receptor , calcium in biology , depolarization , microbiology and biotechnology , biology , programmed cell death , calcium , excitotoxicity , chemistry , biochemistry , glutamate receptor , intracellular , receptor , apoptosis , endocrinology , organic chemistry

The α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptors (AMPAR) subunits can be posttranscriptionally modified by alternative splicing forming flip and flop isoforms. We determined if an ischemia-like insult to retinal ganglion cells (RGCs) increases AMPAR susceptibility to s-AMPA-mediated excitotoxicity through changes in posttranscriptional modified isoforms.

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