Open AccessBimatoprost Increases Mechanosensitivity of Trigeminal Ganglion Neurons Innervating the Inner Walls of Rat Anterior Chambers via Activation of TRPA1
Author(s) -
Yun Ling,
Zhuangli Hu,
Qingkai Meng,
Fang Peng,
Haixia Liu
Publication year - 2016
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.15-18108
Subject(s) - mechanosensitive channels , trigeminal ganglion , bimatoprost , chemistry , anatomy , free nerve ending , patch clamp , stimulation , transient receptor potential channel , receptive field , electrophysiology , ion channel , biology , neuroscience , receptor , sensory system , biochemistry , glaucoma , ocular hypertension
Our previous study found that some trigeminal ganglion (TG) nerve endings in the inner walls of rat anterior chambers were mechanosensitive, and transient receptor potential ankyrin 1 (TRPA1) was an essential mechanosensitive channel in the membrane. To address the effect of bimatoprost on the mechanosensitive TG nerve endings in the inner walls of rat anterior chambers, we investigated its effect on their cell bodies in vitro.