DNA Damage Response in Proliferating Müller Glia in the Mammalian Retina | Zendy

Kaori Nomura-Komoike | Zendy; Fuminori Saitoh | Zendy; Yuta Komoike | Zendy; Hiroki Fujieda | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

DNA Damage Response in Proliferating Müller Glia in the Mammalian Retina

Author(s) -

Kaori Nomura-Komoike,

Fuminori Saitoh,

Yuta Komoike,

Hiroki Fujieda

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18101

Subject(s) - muller glia , retinal regeneration , retina , biology , microbiology and biotechnology , dna damage , retinal , cell cycle , zebrafish , neuroglia , regeneration (biology) , progenitor cell , cell , dna , neuroscience , stem cell , central nervous system , biochemistry , gene

Müller glia, the principal glial cell type in the retina, have the potential to proliferate and regenerate neurons after retinal damage. However, unlike the situation in fish and birds, this capacity of Müller glia is extremely limited in mammals. To gain new insights into the mechanisms that hamper retinal regeneration in mammals, we examined the cell cycle progression and DNA damage response in Müller glia after retinal damage.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research