Regeneration of Corneal Epithelium With Dental Pulp Stem Cells Using a Contact Lens Delivery System | Zendy

Evgeny Kushnerev | Zendy; Susan Shawcross | Zendy; Shankari Sothirachagan | Zendy; Fiona Carley | Zendy; Arun Brahma | Zendy; J.R. Yates | Zendy; M Chantal Hillarby | Zendy

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Regeneration of Corneal Epithelium With Dental Pulp Stem Cells Using a Contact Lens Delivery System

Author(s) -

Evgeny Kushnerev,

Susan Shawcross,

Shankari Sothirachagan,

Fiona Carley,

Arun Brahma,

J.R. Yates,

M Chantal Hillarby

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17953

Subject(s) - corneal epithelium , cornea , dental pulp stem cells , stem cell , regeneration (biology) , progenitor cell , contact lens , confocal microscopy , microbiology and biotechnology , pathology , anatomy , ophthalmology , medicine , biology

The corneal epithelium is sloughed off surface of the eye by the action of blinking and is continually replaced by division and maturation of the limbal stem cells (LSCs). In the case of injury or disease, LSCs can be lost or damaged to a point at which the corneal epithelial layer is no longer maintained. leading to LSC deficiencies (LSCDs). When this occurs, the opaque conjunctiva overgrows the anterior surface of the eye, leading to vision impairment or loss. Dental pulp stem cells (DPSCs) are promising candidates as autologous LSC substitutes. In this study, contact lenses (CLs) are used as a novel medical device to deliver DPSCs onto corneal surface to enhance corneal epithelium regeneration.

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