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The aim of the study is to validate and calibrate the Doppler spectral-domain optical coherence tomography (SD-OCT) derived total retinal blood flow (TRBF) and metabolic hyperspectral retinal camera (MHRC) derived oxygen saturation (SO2) of major retinal vessels in human volunteers using a novel and exact provocation technique (RespirAct) that allows the precise control of the end-tidal partial pressure of oxygen (PETO2). Between visit repeatability of the TRBF and retinal blood SO2 also were studied.

Intervisit Repeatability of Retinal Blood Oximetry and Total Retinal Blood Flow Under Varying Systemic Blood Gas Oxygen Saturations