Hypothermia Promotes Survival of Ischemic Retinal Ganglion Cells | Zendy

Katja Reinhard | Zendy; Marion Mutter | Zendy; Elisabeth Gustafsson | Zendy; Leon Gustafsson | Zendy; Martin Vaegler | Zendy; Maximilian Schultheiß | Zendy; Sebastian Müller | Zendy; Efdal Yoeruek | Zendy; Merle Schrader | Zendy; Thomas A. Münch | Zendy

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Hypothermia Promotes Survival of Ischemic Retinal Ganglion Cells

Author(s) -

Katja Reinhard,

Marion Mutter,

Elisabeth Gustafsson,

Leon Gustafsson,

Martin Vaegler,

Maximilian Schultheiß,

Sebastian Müller,

Efdal Yoeruek,

Merle Schrader,

Thomas A. Münch

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17751

Subject(s) - retina , ganglion , ischemia , hypothermia , medicine , retinal ganglion cell , retinal , electroretinography , ophthalmology , anesthesia , anatomy , neuroscience , biology

Ischemic stroke in retinal arteries leads to death of neural tissue and ultimately to blindness. The retina is known to die within 4 hours after onset of ischemia. It is debated whether hypothermia might increase the time window for medical treatment and thereby the chance of recovering sight. In order to characterize the time course of cell death during ischemia and potential beneficial effects of hypothermia in more detail, we investigated the survival of ganglion cells in ischemic pig and human retina as a function of time and temperature.

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