Activation of Prostaglandin FP and EP2 Receptors Differently Modulates Myofibroblast Transition in a Model of Adult Primary Human Trabecular Meshwork Cells | Zendy

Georges Kalouche | Zendy; Fanny Béguier | Zendy; Michael Bakria | Zendy; Stéphane Melik Parsadaniantz | Zendy; Caroline Leriche | Zendy; Thomas Debeir | Zendy; William Rostène | Zendy; Christophe Baudouin | Zendy; Xavier Vigé | Zendy

Open Access

Activation of Prostaglandin FP and EP2 Receptors Differently Modulates Myofibroblast Transition in a Model of Adult Primary Human Trabecular Meshwork Cells

Author(s) -

Georges Kalouche,

Fanny Béguier,

Michael Bakria,

Stéphane Melik Parsadaniantz,

Caroline Leriche,

Thomas Debeir,

William Rostène,

Christophe Baudouin,

Xavier Vigé

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17693

Subject(s) - trabecular meshwork , myofibroblast , prostaglandin e2 receptor , rho kinase inhibitor , chemistry , microbiology and biotechnology , rho associated protein kinase , stress fiber , actin , focal adhesion , phosphorylation , receptor , fibrosis , medicine , biology , biochemistry , glaucoma , neuroscience , agonist

Prostaglandin F2α analogues are the first-line medication for the treatment of ocular hypertension (OHT), and prostanoid EP2 receptor agonists are under clinical development for this indication. The goal of this study was to investigate the effects of F prostanoid (FP) and EP2 receptor activation on the myofibroblast transition of primary trabecular meshwork (TM) cells, which could be a causal mechanism of TM dysfunction in glaucoma.

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