Interleukin-17A Induces IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome | Zendy

Shujie Zhang | Zendy; Ning Yu | Zendy; Rong Zhang | Zendy; Shenghai Zhang | Zendy; Jihong Wu | Zendy

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Interleukin-17A Induces IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome

Author(s) -

Shujie Zhang,

Ning Yu,

Rong Zhang,

Shenghai Zhang,

Jihong Wu

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17578

Subject(s) - inflammasome , microbiology and biotechnology , interleukin 17 , secretion , interleukin , flow cytometry , gene silencing , p38 mitogen activated protein kinases , mapk/erk pathway , caspase 1 , cytokine , chemistry , signal transduction , downregulation and upregulation , interleukin 8 , interleukin 22 , biology , inflammation , immunology , biochemistry , gene

Inflammasome activation and IL-1β production have been proposed to have an important role in age-related macular degeneration (AMD). Growing evidence is emerging for involvement of interleukin-17A (IL-17A) in AMD pathogenesis. We investigated the effects of IL-17A on the activation of inflammasome and production of IL-1β in primary human RPE cells.

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