Recombinant Human VEGF165b Inhibits Experimental Choroidal Neovascularization | Zendy

Jing Hua | Zendy; Christine Spee | Zendy; Satoru Kase | Zendy; Emma Rennel | Zendy; Anette Magnussen | Zendy; Yan Qiu | Zendy; Alexander H. R. Varey | Zendy; Sandeep Dhayade | Zendy; A Churchill | Zendy; Steven J. Harper | Zendy; David O. Bates | Zendy; David R. Hinton | Zendy

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Recombinant Human VEGF₁₆₅b Inhibits Experimental Choroidal Neovascularization

Author(s) -

Jing Hua,

Christine Spee,

Satoru Kase,

Emma Rennel,

Anette Magnussen,

Yan Qiu,

Alexander H. R. Varey,

Sandeep Dhayade,

A Churchill,

Steven J. Harper,

David O. Bates,

David R. Hinton

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4360

Subject(s) - choroidal neovascularization , vascular endothelial growth factor , macular degeneration , neovascularization , angiogenesis , ranibizumab , medicine , vascular endothelial growth factor a , pegaptanib , pathology , bevacizumab , cancer research , ophthalmology , vegf receptors , chemotherapy

Vascular endothelial growth factor (VEGF-A) is the principal stimulator of angiogenesis in wet age-related macular degeneration (AMD). However, VEGF-A is generated by alternate splicing into two families, the proangiogenic VEGF-A(xxx) family and the antiangiogenic VEGF-A(xxx)b family. It is the proangiogenic family that is responsible for the blood vessel growth seen in AMD.

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