Open AccessExploration of Copper-Cysteamine Nanoparticles as a New Type of Agents for Antimicrobial Photodynamic Inactivation
Author(s) -
Liyi Huang,
Li Ma,
Weijun Xuan,
Xiumei Zhen,
Han Zheng,
Wei Chen,
Michael R. Hamblin
Publication year - 2019
Publication title -
journal of biomedical nanotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.558
H-Index - 75
eISSN - 1550-7041
pISSN - 1550-7033
DOI - 10.1166/jbn.2019.2829
Subject(s) - bacteria , enterococcus faecalis , cysteamine , acinetobacter baumannii , antimicrobial , staphylococcus aureus , chemistry , escherichia coli , microbiology and biotechnology , gram negative bacteria , reactive oxygen species , singlet oxygen , gram positive bacteria , bacterial cell structure , biology , biochemistry , oxygen , pseudomonas aeruginosa , genetics , organic chemistry , gene
Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis ) and gram-negative bacteria ( Escherichia coli and Acinetobacter baumannii ), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.