Open AccessSelf-Assembled Lipid Nanomedicines for siRNA Tumor Targeting
Author(s) -
Yu Cheng Tseng,
Leaf Huang
Publication year - 2009
Publication title -
journal of biomedical nanotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.558
H-Index - 75
eISSN - 1550-7041
pISSN - 1550-7033
DOI - 10.1166/jbn.2009.1044
Subject(s) - nanomedicine , nanotechnology , drug delivery , endosome , nanoparticle , liposome , drug carrier , materials science , chemistry , biophysics , biochemistry , biology , cell
Lipid-based nanoparticle technology has developed from chemical drug carrier into an efficient multifunctional siRNA tumor targeting delivery system. In this review, we start with an overview of the lipid-based nanomedicine history and the two classes of lipidic vectors for DNA or siRNA delivery. Then we discuss the features of lipid-based nanomedicine that lead to effective tumor targeting and the principles behind. We also discuss nanoparticle surface modification, classes of tumor targeting ligands, and other state-of-the-art strategies for enhancing endosome release primarily focused on lipid-based systems. At the end, we show that multifunctional self-assembled lipid-based nanoparticles could also be versatile delivery vehicles for cancer molecular imaging probes.