Open AccessSP110b Controls Host Immunity and Susceptibility to Tuberculosis
Author(s) -
Jia-Shiun Leu,
Meiling Chen,
So-Yi Chang,
SungLiang Yu,
Ching-Yi Lin,
Hsuan Wang,
Wan-Chen Chen,
Chia-Hsuin Chang,
JannYuan Wang,
LiNa Lee,
Chong-Jen Yu,
Igor Kramnik,
Bo-Shiun Yan
Publication year - 2017
Publication title -
american journal of respiratory and critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.272
H-Index - 374
eISSN - 1535-4970
pISSN - 1073-449X
DOI - 10.1164/rccm.201601-0103oc
Subject(s) - tuberculosis , immunity , mycobacterium tuberculosis , innate immune system , tumor necrosis factor alpha , downregulation and upregulation , immunology , macrophage , immune system , medicine , biology , gene , genetics , pathology , in vitro
How host genetic factors affect Mycobacterium tuberculosis (Mtb) infection outcomes remains largely unknown. SP110b, an IFN-induced nuclear protein, is the nearest human homologue to the mouse Ipr1 protein that has been shown to control host innate immunity to Mtb infection. However, the function(s) of SP110b remains unclear.