SP110b Controls Host Immunity and Susceptibility to Tuberculosis | Zendy

Jia-Shiun Leu | Zendy; Meiling Chen | Zendy; So-Yi Chang | Zendy; SungLiang Yu | Zendy; Chia-Wei Lin | Zendy; Hsuan Wang | Zendy; Wan-Chen Chen | Zendy; ChinHao Chang | Zendy; JannYuan Wang | Zendy; LiNa Lee | Zendy; ChongJen Yu | Zendy; Igor Kramnik | Zendy; BoShiun Yan | Zendy

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SP110b Controls Host Immunity and Susceptibility to Tuberculosis

Author(s) -

Jia-Shiun Leu,

Meiling Chen,

So-Yi Chang,

SungLiang Yu,

Chia-Wei Lin,

Hsuan Wang,

Wan-Chen Chen,

ChinHao Chang,

JannYuan Wang,

LiNa Lee,

ChongJen Yu,

Igor Kramnik,

BoShiun Yan

Publication year - 2017

Publication title -

american journal of respiratory and critical care medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.272

H-Index - 374

eISSN - 1535-4970

pISSN - 1073-449X

DOI - 10.1164/rccm.201601-0103oc

Subject(s) - tuberculosis , immunity , mycobacterium tuberculosis , innate immune system , tumor necrosis factor alpha , downregulation and upregulation , immunology , macrophage , immune system , medicine , biology , gene , genetics , pathology , in vitro

How host genetic factors affect Mycobacterium tuberculosis (Mtb) infection outcomes remains largely unknown. SP110b, an IFN-induced nuclear protein, is the nearest human homologue to the mouse Ipr1 protein that has been shown to control host innate immunity to Mtb infection. However, the function(s) of SP110b remains unclear.

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