Open AccessSuperoxide Dismutase Improves Oxygenation and Reduces Oxidation in Neonatal Pulmonary Hypertension
Author(s) -
Satyanarayana Lakshminrusimha,
James A. Russell,
Stephen Wedgwood,
Sylvia F. Gugino,
Jeffrey A. Kazzaz,
Jonathan M. Davis,
Robin H. Steinhorn
Publication year - 2006
Publication title -
american journal of respiratory and critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.272
H-Index - 374
eISSN - 1535-4970
pISSN - 1073-449X
DOI - 10.1164/rccm.200605-676oc
Subject(s) - medicine , oxygenation , nitrotyrosine , isoprostane , pulmonary hypertension , nitric oxide , superoxide dismutase , lung , hypoxic pulmonary vasoconstriction , anesthesia , oxidative stress , endocrinology , nitric oxide synthase , lipid peroxidation
Hyperoxic ventilation in the management of persistent pulmonary hypertension of the newborn (PPHN) can result in the formation of reactive oxygen species, such as superoxide anions, which can inactivate nitric oxide (NO) and cause vasoconstriction and oxidation.